Atlético Nacional vs São Paulo Prediction, Betting Tips, Lineups & Odds | 12 Aug 2025

Copa Libertadores Betting Preview: Atlético Nacional vs São Paulo

Colombian Categoria Primera A club Atlético Nacional host Brazilian Série A side São Paulo in the first leg of this Copa Libertadores round of 16 tie at Estadio Atanasio Girardot, with kick-off set for 08:30 on Wednesday 13 August. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats and team news.

Can São Paulo Keep the Scores Close?

When São Paulo clash against Atlético Nacional, we will take the former at 1.87 on the Asian Handicap +0.25. With our stake divided between 0 and +0.5, the visitors look as though they can land a return by swerving defeat.

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Both Teams Victorious in Last Game

Atlético Nacional beat Alianza Petrolera 3-0 at home in their last game. Los Verdolagas recorded 56% possession and had six shots on target, with Facundo Batista, Juan Zapata and Andrés Sarmiento on the scoresheet.

São Paulo won their previous game, beating Vitória at home. It was a 2-0 Série A triumph. Tricolor Paulista managed four shots on goal and enjoyed 57% possession, with Damian Bobadilla and Sabino finding the net.

Copa Libertadores		G	W	D	L	GF	GA	GD	GD	P
1	São Paulo	6	4	2	0	10	4	6	10:4	14
2	Atlético Nacional	6	3	0	3	7	6	1	7:6	9

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Confirmed Lineups

Atlético Nacional confirmed lineup (4-2-3-1): David Ospina (GK), Felipe Roman, Juan Jose Arias, William Tesillo, Camilo Candido, Jorman Campuzano, Juan Zapata, Marino Hinestroza, Edwin Cardona, Marlos Moreno, Alfredo Morelos.

São Paulo confirmed lineup (3-5-2): Rafael (GK), Nahuel Ferraresi, Sabino, Alan Franco, Cedric Soares, Alisson, Damian Bobadilla, Marcos Antonio, Enzo Hernan Diaz, Luciano Neves, Andre.

Atlético Nacional vs São Paulo Prediction & Betting Tips

Discover the top Atlético Nacional vs São Paulo betting angles — from our trusted match prediction and likely score to the best prop plays and a customized bet builder.

Match Prediction

Wager on São Paulo +0.25 on the Asian Handicap at 1.87 for this Copa Libertadores game. We’re keen on their prospects of outperforming their match winner price and this wager looks like good value.

It’s always a case of checking out the latest Copa Libertadores team news to make expert football predictions. Then we get to work when it comes to unearthing the stats that are the most valuable.

Key Atlético Nacional vs São Paulo Copa Libertadores & league stats:

• The +0.25 line has been covered by São Paulo in 6 consecutive games.
• The +0.25 line has been covered by São Paulo in 15 of their last 20 games.
• The +0.25 line has been covered by São Paulo in 7 of their last 10 games.
• The -0.25 line hasn’t been covered by Nacional in 3 of their last 5 games.
• The -0.25 line hasn’t been covered by Nacional in 11 of their last 20 games.

São Paulo +0.25 Probability

The best betting apps make it a 53.5% chance that our pick is settled as a winner. However, we have this number closer to 60% based on our in-depth research. This is why we can recommend this wager.

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Our Match Prediction

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Correct Score Prediction

Nacional 0 - 1 São Paulo

We’re betting on São Paulo to secure a 1-0 winning scoreline. Odds of 7.50 can be taken and it’s great fun to predict a correct score and hopefully land a winner.

Player Prop Picks

Atlético Nacional vs São Paulo Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Nacional Trading at Shorter Odds Than São Paulo

Favourites Atlético Nacional are regarded as the likeliest winners for this Copa Libertadores clash. The 2.10 about them triumphing means a 48% chance of coming out on top based on their current betting odds. At 3.95, São Paulo are regarded as having a lower probability of winning.

There’s the option to get some insurance on your bet by going down the Draw No Bet route. This allows you to back Nacional at 1.44 with a safety net or alternatively opt for São Paulo at 2.55.

The Total Goals odds suggest that Under 2.5 is the likelier outcome in this contest. If you anticipate that a minimum of one side can manage a clean sheet, you might want to take the 1.57 about Both Teams to Score No.

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Alfredo Morelos Favourite to Be First Goalscorer

You will find Alfredo Morelos at 4.40 to be First Goalscorer which makes him the favourite. There’s the chance to get 2.50 that he finds the net at anytime.

Latest Copa Libertadores and domestic league stats. Full Time Result, Goals, Corners and Possession.

Atlético Nacional Stats

São Paulo Stats

Full-Time Result

• 5 wins, 3 defeats and 2 draws in the previous 10 matches
• 5 wins, 3 defeats and 2 draws in the previous 10 home matches

Full-Time Result

• 5 wins, 4 defeats and 1 draw in the previous 10 matches
• 2 wins, 4 defeats and 4 draws in the previous 10 away matches

Goals

• An average of 1.60 goals scored and 1.00 conceded in the previous 10 matches
• An average of 1.90 goals scored and 1.00 conceded in the previous 10 home matches
• An average of 2.60 goals per game in the previous 10 matches
• An average of 2.90 goals per game in the previous 10 home matches
• BTTS Yes in 7 of the previous 10 matches
• BTTS Yes in 6 of the previous 10 home matches
• Over 2.5 Goals in 7 of the previous 10 matches
• Over 2.5 Goals in 7 of the previous 10 home matches

Goals

• An average of 1.40 goals scored and 1.30 conceded in the previous 10 matches
• An average of 1.00 goals scored and 1.30 conceded in the previous 10 away matches
• An average of 2.70 goals per game in the previous 10 matches
• An average of 2.30 goals per game in the previous 10 away matches
• BTTS Yes in 5 of the previous 10 matches
• BTTS Yes in 6 of the previous 10 away matches
• Over 2.5 Goals in 5 of the previous 10 matches
• Over 2.5 Goals in 5 of the previous 10 away matches

Atlético Nacional vs São Paulo Lineups & Team News

Always review the Nacional vs São Paulo team news before locking in your bets. We’ll bring you both the expected and confirmed lineups for the Copa Libertadores, along with current injury news.