Estudiantes vs Cerro Porteño Prediction, Betting Tips, Lineups & Odds | 20 Aug 2025

Copa Libertadores Betting Preview: Estudiantes vs Cerro Porteño

Argentine Primera División club Estudiantes host Paraguayan Primera División side Cerro Porteño in the second leg of this Copa Libertadores round of 16 tie, with kick-off set for 06:00 on Thursday 21 August. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and confirmed lineups.

Don’t Write Off Cerro Porteño For This Clash

Cerro Porteño +0.75 at 1.94 on the Asian Handicap looks like a sensible plan of attack, with our stake divided between +0.5 and +1.0 when they clash with Estudiantes. We’re expecting defeat to be avoided.

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Estudiantes 1-0 First Leg Winners

Estudiantes de La Plata were beaten last game and this was away from home. Banfield claimed a 3-2 Argentine Primera División win. Eduardo Dominguez's side had most of the ball enjoying 59% possession and six shots on target, with Santiago Arzamendia and Roman Gomez each scoring one goal.

Cerro Porteño triumphed in their previous game. This was a 4-3 road win against Club Guarani in the Paraguayan Primera División.

Head-to-Head Statistics

Estudiantes beat Cerro Porteño 1-0 away in the first leg, with Santiago Ascacíbar converting a late penalty. The Argentines enjoyed 61% possession, though the hosts won the shots on target 5-3.

Copa Libertadores		G	W	D	L	GF	GA	GD	GD	P
1	Estudiantes	6	4	0	2	11	5	6	11:5	12
2	Cerro Porteño	6	2	1	3	7	11	-4	7:11	7

View Full Table

Confirmed Lineups

Estudiantes confirmed lineup (4-2-3-1): Fernando Muslera (GK), Roman Gomez, Leandro Gonzalez Pirez, Facundo Rodriguez, Santiago Arzamendia, Mikel Amondarain, Cristian Medina, Tiago Palacios, Santiago Ascacibar, Alexis Castro, Guido Carrillo.

Cerro Porteño confirmed lineup (4-2-3-1): Alexis Arias (GK), Fabricio Dominguez, Lucas Quintana, Matias Perez, Blas Riveros, Robert Piris, Jorge Morel, Juan Iturbe, Federico Carrizo, Ignacio Aliseda, Jonathan Torres.

Estudiantes vs Cerro Porteño Prediction & Betting Tips

We’ve lined up expert Estudiantes vs Cerro Porteño betting tips, from our match prediction and correct score call to player prop picks and best bet builder advice. Read on for the full breakdown.

Match Prediction

Cerro Porteño +0.75 could be the best way forward at odds of 1.94 in this Copa Libertadores encounter. We feel optimistic that the underdogs can punch above their weight and be tough to beat.

The latest injury and suspension news can have a big bearing and we use this data as well as the latest form guide. We’re also keen to study the football stats so that we can get the fullest picture of how the action might happen.

Key Estudiantes vs Cerro Porteño Copa Libertadores & league stats:

• The +0.75 line has been covered by Cerro Porteño in 5 consecutive games on the road.
• The +0.75 line has been covered by Cerro Porteño in 9 of their last 10 games.
• The +0.75 line has been covered by Cerro Porteño in 16 of their last 20 games.
• The -0.75 line hasn’t been covered by Estudiantes in 12 of their last 20 games.

Cerro Porteño +0.75 Probability

According to the odds, there’s a 51.5% likelihood of our pick winning. Taking all factors into consideration, our tipsters think there’s a stronger chance of success and estimate the probability to be closer to 60%. It’s why we think it’s worth placing this wager.

If you’re looking for a good alternative to backing Cerro Porteño on the Asian Handicap, then consider the Winning Margin market. You can choose from a range of fixed intervals and odds.

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Our Match Prediction

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Correct Score Prediction

Estudiantes 1 - 1 Cerro Porteño

An exciting wager could be the game to end in a 1-1 draw at odds of 6.25. A correct score bet provides a fun alternative and a nice potential return on the cards.

Player Prop Picks

Estudiantes vs Cerro Porteño Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Bookies Make Estudiantes Favourites to Win

Estudiantes are the shortest price to win this Copa Libertadores clash according to the bookies, with the favourites given a 58% probability due to their 1.71 betting odds. If you’re interested in wagering Cerro Porteño, you can get 5.50 for the underdog.

If you want to back the favourites to be ahead by the break, then Estudiantes are 2.38 on the Half-Time Result market. Alternatively, Cerro Porteño are 5.50 and the draw is priced at 2.10.

For those anticipating a low-scoring contest, Under 2.5 is the market leader for the Total Goals market. A different angle is going for a BTTS wager and there’s 1.61 available for Both Teams to Score No.

There are hundreds of markets from which to select your preferred wager when it comes to Copa Libertadores games. The best football betting sites push the boat out to provide lots of choice.

Guido Carrillo Favourite to Find the Net First

Guido Carrillo is available at 2.70 when it comes to Anytime Goalscorer. The favourite is now priced at odds of 5.10 to find the net first.

Latest Copa Libertadores and domestic league stats. Full Time Result, Goals, Corners and Possession.

Estudiantes Stats

Cerro Porteño Stats

Full-Time Result

• 3 wins, 5 defeats and 2 draws in the previous 10 matches
• 6 wins, 1 defeat and 3 draws in the previous 10 home matches

Full-Time Result

• 7 wins and 3 draws in the previous 10 matches
• 8 wins, 1 defeat and 1 draw in the previous 10 away matches

Goals

• An average of 0.80 goals scored and 1.50 conceded in the previous 10 matches
• An average of 1.60 goals scored and 0.90 conceded in the previous 10 home matches
• An average of 2.30 goals per game in the previous 10 matches
• An average of 2.50 goals per game in the previous 10 home matches
• BTTS Yes in 4 of the previous 10 matches
• BTTS Yes in 6 of the previous 10 home matches
• Over 2.5 Goals in 4 of the previous 10 matches
• Over 2.5 Goals in 5 of the previous 10 home matches

Goals

• An average of 2.40 goals scored and 1.10 conceded in the previous 10 matches
• An average of 2.50 goals scored and 1.00 conceded in the previous 10 away matches
• An average of 3.50 goals per game in the previous 10 matches
• An average of 3.50 goals per game in the previous 10 away matches
• BTTS Yes in 7 of the previous 10 matches
• BTTS Yes in 6 of the previous 10 away matches
• Over 2.5 Goals in 6 of the previous 10 matches
• Over 2.5 Goals in 6 of the previous 10 away matches

Estudiantes vs Cerro Porteño Lineups & Team News

The latest Estudiantes vs Cerro Porteño team news could impact your bets — review it first. Stay informed with our predicted and confirmed Copa Libertadores lineups and the latest injury reports.