Santos Laguna vs San Luis Prediction, Betting Tips, Lineups & Odds | 21 Sep 2025

Liga MX Betting Preview: Santos Laguna vs San Luis

Santos Laguna host San Luis in this Liga MX clash at Estadio Nuevo Corona, with kick-off set for 07:00 on Monday 22 September. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

Over 2.5 Goals Looks the Value Bet

We are sweet on the prospect of the net bulging when Santos Laguna clash with San Luis. On this basis, we will side with the Over 2.5 pick when it comes to Total Goals, feeling confident with the 1.64 that is on offer.

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3-2 Win for San Luis in Last H2H Battle

Santos Laguna faced Atlas away when last in action. It was a 2-2 draw at Estadio Jalisco. Francisco Rodriguez's team had nine shots on target and enjoyed 64% possession, while Jonathan Perez Sanchez and Jesus Ocejo scored one goal each.

Atlético San Luis hosted Club Tijuana at Estadio Alfonso Lastras in their previous game, ending in a 1-1 draw. Los Atléticos were 49% in the possession stakes and had three shots on goal, with Benjamin Galdames on the scoresheet.

Head-to-Head Statistics

It has been three successive wins for San Luis when playing Santos. In their last clash, San Luis travelled to Estadio Nuevo Corona and landed a 3-2 victory. The previous 10 H2H meetings have yielded four wins apiece and two draws.

Liga MX		G	W	D	L	GF	GA	GD	GD	P
13	Santos Laguna	8	2	1	5	11	13	-2	11:13	7
14	San Luis	8	2	1	5	11	14	-3	11:14	7

View Full Table

2 wins, 7 losses and 1 draw, averaging 1.1 goals from 6.8 attempts and 3.1 shots on goal. Santos have had 46.0% possession and 4.0 corners per match. On average, the opposition have scored 1.9 goals from 12.9 attempts and 5.9 shots on goal, while earning 6.3 corners.

Top scorer Cristian Dajome has found the net 3 times, with Jesus Ocejo, Bruno Barticciotto and Ramiro Sordo getting 2 each. Jose Abella is the leading assists maker on 2.

San Luis have 3 victories, 6 defeats and 1 draw, with an average of 3.9 shots on goal, 7.1 attempts and 1.3 goals. Los Atléticos average 48.5% possession, 5.1 corners awarded and 5.7 corners against, while 1.6 goals have been conceded from 10.1 attempts and 5.3 shots on goal.

Joao Pedro has top scored with 6, while Benjamin Galdames and Roman Torres are next best on 2. Sebastien Lamonge has managed 2 assists in the last 10 games.

Predicted & Confirmed Lineups

Santos Laguna predicted lineup (4-2-3-1): Carlos Acevedo Lopez (GK), José Javier Abella, Óscar Haret Ortega, Kevin Balanta, Bruno Amione, Kevin Palacios, Javier Güemez, Cristian Dájome, Aldo López Vargas, Ramiro Sordo, Bruno Barticciotto.

San Luis predicted lineup (4-3-3): Andrés Sánchez (GK), Jose Javier Suarez, Robson Bambu, Eduardo Águila, Juan Manuel Sanabria, Óscar Macías, Sébastien Salles Lamonge, Rodrigo Dourado, Miguel García, João Pedro Galvão, Benjamín Galdames.

Santos Laguna vs San Luis Prediction & Betting Tips

Head into Santos Laguna vs San Luis with expert betting insights, including our main match prediction, expected scoreline, top corners angle, key player props and a thoughtfully built bet builder.

Match Prediction

There’s a strong chance that we’ll see at least three goals scored for this Liga MX game. As a result, we’ll go for Over 2.5 Goals and the available odds of 1.64 look really attractive.

The football betting tips are only provided once we have a handle on the team news and the latest form guide. We are also on point when it comes to the most valuable Liga MX stats.

Key Santos Laguna vs San Luis league stats:

• The 2.5 line has been covered in 13 of the last 20 Santos games.
• The 2.5 line has been covered in 6 of the last 10 Santos games.
• The 2.5 line has been covered in 7 of the last 10 San Luis games on the road.
• The 2.5 line has been covered in 13 of the last 20 San Luis games.
• The 2.5 line has been covered in the last 3 games between these teams.

Over 2.5 Probability

The latest odds at the best betting sites suggest our pick carries a 61% chance of winning. However, we have this number closer to 70% based on our in-depth research. It is therefore regarded as a value wager.

If Over 2.5 Goals is something that appeals but you want more juice, consider the option of heading to the Result & Total Goals market. Adding this selection with a team to win is a potential way forward.

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Our Match Prediction

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Correct Score Prediction

Santos 1 - 2 San Luis

There’s plenty of juice to be found by backing San Luis to win 2-1. We can’t pass up the odds of 8.50 when it comes to correct score betting and it’s a fun wager.

Player Prop Picks

Corners Prediction

San Luis Over 5.5 Corners

The 5.5 corners line has been covered by San Luis in five consecutive away games, while Santos have conceded 7.60 corners on average in their last 5 matches. We think that there’s a strong case for this outcome and we’ll back San Luis to cover the Team Corners line which is available at odds of 1.90.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Santos

Total

10.30 4.00 6.30

Home

10.40 4.70 5.70

Away

11.50 4.60 6.90

San Luis

Total

10.80 5.10 5.70

Home

9.40 4.50 4.90

Away

11.90 5.50 6.40

Latest Corner Odds

Total Corners

Santos Corners

San Luis Corners

Most Corners

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Santos Laguna vs San Luis Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Close Contest Expected According to Latest Odds

The bookies have priced up the Full-Time Result betting odds and Atlético San Luis are 2.43 to land a Liga MX victory, while Santos Laguna are 2.55 to win. The draw is trading at 3.65 should you think the clash will end all square.

There are various ways to back San Luis and one option is the Asian Handicap -0.25. There’s 2.14 currently available that they beat Santos and there’s half a stake refund if the scoreline ends level.

The odds suggest that Over 2.5 Goals is a strong probability in this exciting contest. If you’re anticipating that both teams will score, the BTTS Yes option can be wagered at 1.55.

The best football betting sites provide bettors with an abundance of options. For every Liga MX game, you’re able to select from hundreds of markets and make the best choice.

João Galvão Shortest Odds for First Goalscorer

João Galvão is available at 2.40 when it comes to Anytime Goalscorer, with the favourite priced at odds of 4.80 to find the net first.

Six Defeats for Santos in Previous Ten Home Encounters

Santos have clocked up six losses and four wins in the past 10 home games, recording an average of 1.30 goals per match and conceding 1.60.

San Luis have finished with seven defeats and three wins in the past 10 away games, netting an average of 1.40 goals per match and conceding 2.10.

The last Estadio Nuevo Corona meeting saw San Luis beat Santos 3-2. The 6 H2H games most recently played at Estadio Nuevo Corona have included three Santos victories, one draw and two triumphs for San Luis.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
Santos Laguna Home Stats		4-0-6	2.90	1.30	1.60	6	4	4	6
San Luis Away Stats		3-0-7	3.50	1.40	2.10	7	3	6	4

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

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Santos Laguna vs San Luis Lineups & Team News

Make sure to look over the Santos vs San Luis team news before betting. Stay in the know with our predicted and confirmed Liga MX lineups and the latest on injuries.

Santos Laguna Team Page San Luis Team Page