NFL Betting Preview: Colts vs Titans

The Indianapolis Colts face the Tennessee Titans in this NFL Week 3 matchup at Nissan Stadium, with kickoff scheduled for 01:00 on Monday 22 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

A High-Scoring Game On the Cards?

Let’s go for Over 43.5 when the Titans face the Colts. We think the line is too generous and we’re expecting the final total to be higher at 1.94.

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Colts Beat Titans in Pair’s Last Matchup

Indianapolis Colts beat Denver Broncos in their previous game, making it back-to-back victories. It was a 29-28 home win at Lucas Oil Stadium. The Colts put up 473 total yards, made up of 306 through the air and 167 on the ground. The offense managed 26 first downs to go along with two touchdowns.

Tennessee Titans were defeated last time, making it back-to-back losses. Nissan Stadium saw them beaten 33-19 at home to Los Angeles Rams. The Titans moved the ball for 252 yards, including 143 passing and 109 rushing yards. They scored once through the air and picked up 18 first downs.

Head-to-Head Statistics

The Colts beat the Titans in their last head-to-head matchup. It was a 38-30 scoreline at Lucas Oil Stadium. Each franchise has landed five wins in the previous 10 games between these teams.

Quarterbacks

Daniel Jones

Cam Ward

Colts vs Titans Prediction & Picks

Our Colts vs Titans betting tips provide expert coverage of all major angles, including our main match prediction, top player prop picks, correct score recommendation and best bet builder insights.

Game Prediction

There’s juice available when it comes to backing Over 43.5 points in this NFL matchup and that’s the betting angle we’re pursuing. Our pick is priced up at 1.94 which looks worth taking.

We put solid research behind every NFL prediction, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.

Key Colts vs Titans stats:

The 43.5 line has been covered in the last 4 Colts games on the road.
The 43.5 line has been covered in 8 of the last 10 Colts games.
The 43.5 line has been covered in 12 of the last 20 Colts games on the road.

Over 43.5 Probability

The best betting apps make it a 51.5% chance that our pick is settled as a winner. Based on our in-depth research, we calculate the actual probability to be 55-60%. That means we are regarding it as a value wager.

Looking for Bigger Odds?

It’s possible to increase the odds on your Over wager by combining it with other picks. A Bet Builder allows you to place multiple bets from the same game into one single parlay.

Getting ready to place a wager? Check our updated guide for the latest betting offers, including free bets and the newest promos codes.

Best Bet

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Published 07:27, 20 September 2025

Player Prop Picks

Top Pick: Cam Ward Over 198.5 Passing Yards

The odds for Cam Ward (Titans) to rack up over 198.5 passing yards stand at 1.88. The line for QB Passing Yards looks attractive and we’re confident of securing a return.

Latest Cam Ward Player Prop Odds

Touchdown

Passing Yards

Rushing Yards

Michael Pittman Jr. Over 44.5 Receiving Yards

The odds for Michael Pittman Jr. (Titans) to go beyond 44.5 receiving yards are 1.88. There’s an opportunity to place a Player Receiving Yards bet, with him capable of covering an appealing line.

Latest Michael Pittman Jr. Player Prop Odds

Touchdown

Receiving Yards

Same Game Parlay Picks

Totals Over 43.5

Spread Colts -4.5

Passing Yards Cam Ward Over 198.5

Get in the game with a same game parlay. Our picks are Over 43.5 on the total, Colts to cover the -4.5 spread and Cam Ward (Titans) to go Over 198.5 passing yards.

We recommend a same game parlay as it’s an exciting way of wagering on a single event. Many bettors like to create a personalised football bet which reflects their predictions for how a game is going to play out.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Colts

27 - 21 Titans logo

Titans

The Colts might be able to claim a victory and we’re siding with a 27-21 scoreline in their favor. A small stake can provide a big return and there are monster odds available.

Colts vs Titans Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Make Colts Moneyline Favorites

With a 70% chance of securing victory, Indianapolis Colts are favorites for this game and the sportsbooks have them at betting odds of 1.43. For those wanting to back Tennessee Titans, you will find 2.94 about the underdogs.

The spread is calculated to be 5.5, while total points comes in at 43.5. The Totals offers NFL fans an alternative way of getting involved. If you fancy Over 43.5, this outcome can be backed at 1.94.

If a National Football League wager is on your mind, visit the top sportsbooks and check out the huge selection of available game lines and team props. Find the betting odds and lines which are the most appealing.

Moneyline

Point Spread

Total Points

Jonathan Taylor Favorite to Be First TD Scorer

Jonathan Taylor is the First Touchdown Scorer favorite at 3.90. Alternatively, there’s the chance to simply back him to score a TD anytime at 1.45.

Touchdown

Jonathan Taylor (Colts)

Tony Pollard (Titans)

Daniel Jones (Colts)

Tyler Warren (Colts)

View More View Less

Receiving Yards

Calvin Ridley (Titans)

Tyler Warren (Colts)

Michael Pittman Jr. (Colts)

Elic Ayomanor (Titans)

View More View Less

Rushing Yards

Jonathan Taylor (Colts)

Tony Pollard (Titans)

Daniel Jones (Colts)

Cam Ward (Titans)

Passing Yards

Daniel Jones (Colts)

Cam Ward (Titans)

Micro Betting

Micro betting is something that’s really popular with bettors, with NFL fans essentially being able to wager in-game when it comes to score, player and team props. Sometimes these are two-way lines where you can bet on the Next Play or Next Drive.

Best Betting Offers

Nissan Stadium

Titans With Five Consecutive Home Losses

The Titans have endured a run of five straight defeats at Nissan Stadium. They have a 2-8 record in their last 10 home games, putting up 17.50 points on average and giving up 23.70.

The Colts have a 3-7 record in their last 10 games on the road, averaging 20.60 points on offense and surrendering 27.00 on defense.

In their most recent matchup at Nissan Stadium, the Colts got the better of the Titans 20-17. Over the last 6 head-to-head clashes at Nissan Stadium, the Colts have secured four victories, as the Titans have picked up two.

Last 10 Games		W-L	P	PF	PA	O43.5	U43.5
Titans Home Stats		2-8	41.20	17.50	23.70	4	6
Colts Away Stats		3-7	47.60	20.60	27.00	5	5

W-L = Wins-Losses
P = Avg. Points
PF = Avg. Points For
PA = Avg. Points Against
O43.5 = Games Over 43.5 Points
U43.5 = Games Under 43.5 Points

Last 5 & H2H

All
Home
Away

Last 5 Games

Colts

NFL: 14/09 Broncos28 Colts 29
NFL: 07/09 Dolphins8 Colts 33
NFL: 05/01 Jaguars23 Colts 26
NFL: 29/12 Colts33 Giants 45
NFL: 22/12 Titans30 Colts 38

Titans

NFL: 14/09 Rams33 Titans 19
NFL: 07/09 Titans12 Broncos 20
NFL: 05/01 Texans23 Titans 14
NFL: 29/12 Titans13 Jaguars 20
NFL: 22/12 Titans30 Colts 38

Head to Head

Colts vs Titans

NFL: 22/12 2024 Titans 30 Colts 38
NFL: 13/10 2024 Colts 20 Titans 17
NFL: 03/12 2023 Colts 31 Titans 28
NFL: 08/10 2023 Titans 16 Colts 23
NFL: 23/10 2022 Colts 10 Titans 19
NFL: 02/10 2022 Titans 24 Colts 17
NFL: 31/10 2021 Titans 34 Colts 31
NFL: 26/09 2021 Colts 16 Titans 25
NFL: 29/11 2020 Titans 45 Colts 26
NFL: 13/11 2020 Colts 34 Titans 17

Team Stats

Latest regular season and playoff games stats.

Indianapolis Colts Stats

Tennessee Titans Stats

Moneyline

6 wins and 4 defeats in the last 10 games
3 wins and 7 defeats in the last 10 games on the road

Moneyline

1 win and 9 defeats in the last 10 games
2 wins and 8 defeats in the last 10 home games

Point Spread

-4.5 Betting Line: Have covered the spread in 2 of the last 10 games
-4.5 Betting Line on the Road: Have not covered the spread in any of the last 10 games on the road

Point Spread

+4.5 Betting Line: Have covered the spread in 2 of the last 10 games
+4.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

Game Totals: An average of 52.10 pts in the previous 10 games
Game Totals on the Road: An average of 47.60 pts in the previous 10 games on the road
Over 43.5: Covered in 8 of the previous 10 games
Over 43.5 on the Road: Covered in 5 of the previous 10 games on the road
Team Totals: Have scored an average of 25.10 pts and allowed 27.00 pts in the last 10 games
Team Totals on the Road: Have scored an average of 20.60 pts and allowed 27.00 pts in the last 10 games on the road

Total Points

Game Totals: An average of 45.80 pts in the previous 10 games
Game Totals at Home: An average of 41.20 pts in the previous 10 home games
Over 43.5: Covered in 5 of the previous 10 games
Over 43.5 at Home: Covered in 4 of the previous 10 home games
Team Totals: Have scored an average of 18.50 pts and allowed 27.30 pts in the last 10 games
Team Totals at Home: Have scored an average of 17.50 pts and allowed 23.70 pts in the last 10 home games

Game Stats

Last 10 Games

Total Yards: Gained 374.80 Yds. Allowed 322.30 Yds
Rushing Yards: Gained 156.20 Yds. Allowed 108.90 Yds
Passing Yards: Gained 218.60 Yds. Allowed 213.40 Yds
Total Touchdowns: Scored 2.50 TD. Allowed 3.30 TD
Rushing Touchdowns: Scored 1.40 TD. Allowed 1.20 TD
Passing Touchdowns: Scored 1.10 TD. Allowed 1.70 TD
Total 1st Downs: Picked up 20.70. Allowed 18.00
Total Turnovers: Committed 1.60. Committed by opponents 1.40
Total Penalties: Committed 5.80. Committed by opponents 5.40
Penalty Yards: Lost 43.50 Yds. Gained 54.30 Yds

Game Stats

Last 10 Games

Total Yards: Gained 289.70 Yds. Allowed 358.40 Yds
Rushing Yards: Gained 89.80 Yds. Allowed 152.40 Yds
Passing Yards: Gained 199.90 Yds. Allowed 206.00 Yds
Total Touchdowns: Scored 1.70 TD. Allowed 3.40 TD
Rushing Touchdowns: Scored 0.50 TD. Allowed 1.40 TD
Passing Touchdowns: Scored 1.20 TD. Allowed 1.70 TD
Total 1st Downs: Picked up 16.40. Allowed 20.20
Total Turnovers: Committed 2.00. Committed by opponents 1.70
Total Penalties: Committed 8.60. Committed by opponents 7.00
Penalty Yards: Lost 68.40 Yds. Gained 56.70 Yds

Last 10 Games on the Road

Total Yards: Gained 318.60 Yds. Allowed 356.20 Yds
Rushing Yards: Gained 115.20 Yds. Allowed 138.20 Yds
Passing Yards: Gained 203.40 Yds. Allowed 218.00 Yds
Total Touchdowns: Scored 2.20 TD. Allowed 2.90 TD
Rushing Touchdowns: Scored 0.90 TD. Allowed 0.80 TD
Passing Touchdowns: Scored 1.20 TD. Allowed 1.90 TD
Total 1st Downs: Picked up 19.50. Allowed 18.90
Total Turnovers: Committed 2.10. Committed by opponents 1.20
Total Penalties: Committed 5.10. Committed by opponents 5.40
Penalty Yards: Lost 37.50 Yds. Gained 54.80 Yds

Last 10 Home Games

Total Yards: Gained 301.10 Yds. Allowed 336.00 Yds
Rushing Yards: Gained 108.70 Yds. Allowed 117.00 Yds
Passing Yards: Gained 192.40 Yds. Allowed 219.00 Yds
Total Touchdowns: Scored 1.90 TD. Allowed 2.80 TD
Rushing Touchdowns: Scored 0.60 TD. Allowed 0.90 TD
Passing Touchdowns: Scored 1.30 TD. Allowed 1.60 TD
Total 1st Downs: Picked up 18.20. Allowed 19.60
Total Turnovers: Committed 1.70. Committed by opponents 1.50
Total Penalties: Committed 7.90. Committed by opponents 6.80
Penalty Yards: Lost 62.50 Yds. Gained 54.70 Yds

Team News

Indianapolis Colts @ Tennessee Titans Lineups

Tennessee Titans

Manager:

Brian Callahan

Indianapolis Colts

Manager:

Shane Steichen

Tennessee Titans Substitutes

0 Calvin Ridley
1 Cam Ward
3 Johnny Hekker
4 Tyler Lockett
5 Elic Ayomanor
6 Joey Slye
7 Oluwafemi Oladejo
11 Van Jefferson
17 Chimere Dike
18 Jalyn Armour-Davis
20 Tony Pollard
21 Roger McCreary
25 Xavier Woods
26 Marcus Harris
28 Quandre Diggs
31 Kalel Mullings
33 Cedric Gray
36 Julius Chestnut
37 Amani Hooker
38 L'Jarius Sneed
39 Darrell Baker Jr.
42 Kyzir White
44 Mike Brown
45 Dre'Mont Jones
46 Morgan Cox
49 Arden Key
50 Cody Barton
53 Jihad Ward
54 Dorian Mausi
61 John Ojukwu
62 Corey Levin
64 Jackson Slater
69 Sebastian Joseph-Day
72 Olisaemeka Udoh
73 Blake Hance
75 Dan Moore Jr.
77 Peter Skoronski
79 Lloyd Cushenberry III
84 Gunnar Helm
85 Chigoziem Okonkwo
88 David Martin-Robinson
90 Shy Tuttle
91 C.J. Ravenell
92 Jaylen Harrell
96 Carlos Watkins
97 James Lynch
98 Jeffery Simmons

Indianapolis Colts Substitutes

0 Camryn Bynum
1 Josh Downs
3 Spencer Shrader
4 Xavien Howard
5 Anthony Richardson
6 Anthony Gould
7 Charvarius Ward
8 Rigoberto Sanchez
10 Adonai Mitchell
11 Michael Pittman Jr.
14 Alec Pierce
16 Ashton Dulin
17 Daniel Jones
20 Nick Cross
21 DJ Giddens
23 Kenny Moore II
25 Rodney Thomas II
28 Jonathan Taylor
29 Mekhi Blackmon
31 Tyler Goodson
32 Daniel Scott
35 Johnathan Edwards
44 Zaire Franklin
46 Luke Rhodes
48 Joe Bachie
50 Segun Olubi
51 Kwity Paye
52 Samson Ebukam
56 Quenton Nelson
58 Austin Ajiake
59 Cameron McGrone
60 Tanor Bortolini
63 Danny Pinter
68 Dalton Tucker
71 Matt Goncalves
72 Braden Smith
75 Jalen Travis
79 Bernhard Raimann
81 Mo Alie-Cox
84 Tyler Warren
85 Drew Ogletree
90 Grover Stewart
92 Neville Gallimore
94 Tyquan Lewis
95 Adetomiwa Adebawore
97 Laiatu Latu
98 Eric Johnson
99 DeForest Buckner

Indianapolis Colts Injuries

Type

Name

Info

Salvon Ahmed

Ankle

Joe Bachie

Quadriceps

Jaylon Carlies

Ankle

Blake Freeland

Leg

Jaylon Jones

Hamstring

D.J. Montgomery

Undisclosed

Jacob Phillips

Biceps

Bernhard Raimann

Illness

Justin Walley

Knee - ACL

Charvarius Ward

Concussion

Tyler Warren

Toe

Jack Wilson

Undisclosed

Hunter Wohler

Foot

Tennessee Titans Injuries

Type

Name

Info

Jarvis Brownlee

Ankle

Treylon Burks

Collarbone

JC Latham

Hip

Will Levis

Shoulder

Kalel Mullings

Ankle

Bryce Oliver

Knee

Anfernee Orji

Knee - ACL

L'Jarius Sneed

Back

Tyjae Spears

Ankle

T'Vondre Sweat

Ankle

Kevin Winston

Hamstring

Kevin Zeitler

Biceps

Previous Indianapolis Colts Lineups

15 Sep NFL

Broncos 28-29 Colts

AFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bills	3	0	1.000	102	71	31	2-0-0	1-0-0	2-0-0	3-0-0	3-0-0	3W
Patriots	1	2	0.333	60	68	-8	0-2-0	1-0-0	1-0-0	1-2-0	1-2-0	1L
Dolphins	0	3	0.000	56	97	-41	0-1-0	0-2-0	0-2-0	0-3-0	0-3-0	3L
Jets	0	3	0.000	69	93	-24	0-2-0	0-1-0	0-1-0	0-2-0	0-3-0	3L

AFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bengals	2	1	0.667	58	91	-33	1-0-0	1-1-0	1-0-0	2-0-0	2-1-0	1L
Steelers	2	1	0.667	72	77	-5	0-1-0	2-0-0	0-0-0	2-0-0	2-1-0	1W
Ravens	1	1	0.500	81	58	23	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1W
Browns	1	2	0.333	46	68	-22	1-1-0	0-1-0	0-2-0	0-2-0	1-2-0	1W

AFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Chargers	3	0	1.000	70	50	20	2-0-0	1-0-0	3-0-0	3-0-0	3-0-0	3W
Chiefs	1	2	0.333	60	56	4	0-1-0	1-1-0	0-1-0	0-1-0	1-2-0	1W
Raiders	1	2	0.333	53	74	-21	0-1-0	1-1-0	0-1-0	1-1-0	1-2-0	2L
Broncos	1	2	0.333	68	64	4	1-0-0	0-2-0	0-1-0	1-2-0	1-2-0	2L

NFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Eagles	3	0	1.000	77	63	14	2-0-0	1-0-0	1-0-0	2-0-0	3-0-0	3W
Commanders	2	1	0.667	80	57	23	2-0-0	0-1-0	1-0-0	1-1-0	2-1-0	1W
Cowboys	1	2	0.333	74	92	-18	1-0-0	0-2-0	1-1-0	1-2-0	1-2-0	1L
Giants	0	3	0.000	52	83	-31	0-1-0	0-2-0	0-2-0	0-2-0	0-3-0	3L

NFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Packers	2	1	0.667	64	44	20	2-0-0	0-1-0	1-0-0	2-0-0	2-1-0	1L
Vikings	2	1	0.667	81	56	25	1-1-0	1-0-0	1-0-0	1-1-0	2-1-0	1W
Lions	1	1	0.500	65	48	17	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Bears	1	2	0.333	76	93	-17	1-1-0	0-1-0	0-2-0	1-2-0	1-2-0	1W

NFC South	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Buccaneers	3	0	1.000	72	66	6	1-0-0	2-0-0	1-0-0	1-0-0	3-0-0	3W
Falcons	1	2	0.333	42	59	-17	0-1-0	1-1-0	0-2-0	1-2-0	1-2-0	1L
Panthers	1	2	0.333	62	53	9	1-0-0	0-2-0	1-0-0	1-1-0	1-2-0	1W
Saints	0	3	0.000	47	90	-43	0-2-0	0-1-0	0-0-0	0-3-0	0-3-0	3L

NFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
49ers	3	0	1.000	59	49	10	1-0-0	2-0-0	2-0-0	3-0-0	3-0-0	3W
Cardinals	2	1	0.667	62	51	11	1-0-0	1-1-0	0-1-0	2-1-0	2-1-0	1L
Seahawks	2	1	0.667	88	47	41	1-1-0	1-0-0	0-1-0	1-1-0	2-1-0	2W
Rams	2	1	0.667	73	61	12	1-0-0	1-1-0	0-0-0	0-1-0	2-1-0	1L

NFL Betting Preview: Colts vs Titans

Head-to-Head Statistics

Colts vs Titans Prediction & Picks

Game Prediction

Over 43.5 Probability

Best Bet

Player Prop Picks

Same Game Parlay Picks

Correct Score Prediction

Colts vs Titans Odds

Last 5 & H2H

Team News

Indianapolis Colts @ Tennessee Titans Lineups

Tennessee Titans

Indianapolis Colts

Tennessee Titans Substitutes

Indianapolis Colts Substitutes

Indianapolis Colts Injuries

Tennessee Titans Injuries

Previous Indianapolis Colts Lineups

Previous Tennessee Titans Lineups

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